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ZO-1 Recombinant Rabbit mAb - Details |
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Alternative Name |
TJP1; ZO1; Tight junction protein ZO-1; Tight junction protein 1 |
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Recommended Dilutions |
IHC: 1:200-1:500 ICC/IF: 1:100 FC: 1:50 |
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Formulation |
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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Purification |
Affinity Purification |
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Specificity |
IgG |
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Molecular Weight |
195 kDa |
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Immunogen |
Recombinant protein of human ZO-1 |
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Conjugate |
Unconjugated |
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Modification |
Unmodification |
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Swiss-Prot No |
Q07157 |
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Background |
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This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. |
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