Function

catalytic activity + a protein = ADP + a phosphoprotein. Disease: Defects in MASTL are the cause of thrombocytopenia type 2 (THC2) [MIM:188000]. Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting., function: Putative serine/threonine kinase which may be involved in megakaryocyte differentiation., similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family., similarity: Contains 1 AGC-kinase C-terminal domain., similarity: Contains 1 protein kinase domain.

Cellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nucleus . Cleavage furrow . During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Upon mitotic exit moves to the cleavage furrow.

Background

This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus.