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SOX2 (14J6) Rabbit Monoclonal Antibody (AF488 Conjugated) |
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Gene Name |
SOX2 |
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Protein Name |
Transcription factor SOX-2 |
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Clonality |
Monoclonal |
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Conjugation |
AF488 |
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Store Buffer |
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
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Human Gene ID |
6657 |
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Human Swissprot No |
P48431 |
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Mouse Gene ID |
20674 |
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Mouse Swissprot No |
P48432 |
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Dilution level |
IHC-P 1:100-1:500, WB 1:2000-1:10000, IF 1:200-1:1000, ELISA 1:5000-1:20000 |
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Reference molecular weight |
34kDa |
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Predicting molecular weight |
34kDa |
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storage conditions |
Biological ice bag transportation. Store at -20°C for at least 12 months. Avoid freeze/thaw cycles |
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Alternative News |
SOX2; Transcription factor SOX-2 |
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Background |
SRY-box 2(SOX2) Homo sapiens This intron less gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). |
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Cell localization |
Nucleus speckle . Cytoplasm . Nucleus . Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity). |
