RPA p32 (phospho Ser33) Rabbit Polyclonal Antibody

Catalogue No BSAB-009P
Reactivity Human, Mouse, Rat
Host Rabbit
Tested Application WB,WB,IHC-P
Size 20μL | 50μL | 100ul | 200μL
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SKU: BSAB-009P Categories: ,
Altername RPA2; REPA2; RPA32; RPA34; Replication protein A 32 kDa subunit; RP-A p32; Replication factor A protein 2; RF-A protein 2; Replication protein A 34 kDa subunit; RP-A p34
Description Rabbit Polyclonal Antibody
Purification Affinity Purification
Conjugate Unconjugated
Modification Phosphorylated
Isotype IgG
Molecular Weight 32kDa
Clonality Polyclonal Antibody
Form Liquid
Gene Name RPA2
Gene ID 6118
SwissProt ID P15927
Dilution Ratio WB 1:500-2000, IHC-P 1:50-300
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.Thr21 of human RPA32/RPA2
Buffer Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N.

Background

Function: Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.,PTM:Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis). Phosphorylated by ATR upon DNA damage, which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA, and by CDC2.,subcellular location: Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage., subunit: Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN.,function:Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.,PTM:Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis). Phosphorylated by ATR upon DNA damage, which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA, and by CDC2.,subcellular location:Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage.,subunit:Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN.

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