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Recombinant Human Permeability Glycoprotein (Pgp) |
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Description |
Recombinant Human Permeability Glycoprotein (Pgp), expressed in Escherichia coli (E. coli) and purified by standard chromatographic techniques. |
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Formulation Buffer |
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. |
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Purity |
> 97% pure as determined by Silver stained SDS-PAGE analysis. Molecular Weight: ~61KDa |
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Storage |
Shipped at 2-8°C. Aliqote and Storet at-80C; Avoid repeated freeze/thaw cycles. |
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Background |
Permeability Glycoprotein(Pgp) protects the body from harmful substances by: Removing drugs absorbed in the intestines back into the gut lumen. Maintaining the integrity of the blood brain barrier. Removing drugs from the kidneys and liver into the urine and bile respectively. |
