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Recombinant Human Perforin 1 (PRF1) |
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Description |
Recombinant Human Perforin 1 (PRF1), expressed in Escherichia coli (E. coli) and purified by standard chromatographic techniques. |
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Formulation Buffer |
PBS, pH7.4, containing 0.01% SKL, 5% Trehalose |
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Purity |
> 95% pure as determined by Silver stained SDS-PAGE analysis. Molecular Weight: ~62KDa |
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Storage |
Shipped at 2-8°C. Aliqote and Storet at-80C; Avoid repeated freeze/thaw cycles. |
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Background |
Perforin1(PRF1), pore-forming protein that plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. |
