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Recombinant Human Low Density Lipoprotein Receptor Related Protein 5 (LRP5) |
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Description |
Recombinant Human Low Density Lipoprotein Receptor Related Protein 5 (LRP5), expressed in Escherichia coli (E. coli) and purified by standard chromatographic techniques. |
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Formulation Buffer |
20mM Tris,150mM NaCl,pH8.0,containing 1mM EDTA,1mM DTT,0.01% SKL, 5% Trehalose and Proclin30 |
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Purity |
> 90% pure as determined by Silver stained SDS-PAGE analysis. Molecular Weight: ~33KDa |
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Storage |
Shipped at 2-8°C. Aliqote and Storet at-80C; Avoid repeated freeze/thaw cycles. |
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Background |
Low-density lipoprotein receptor-related protein 5(LRP5) is a protein that in humans is encoded by the LRP5 gene. LRP5 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. Mutations in LRP5 can lead to considerable changes in bone mass. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the Canonical Wnt Pathway. This protein plays a key role in skeletal homeostasis. |
