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Recombinant Human Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7) |
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Description |
Recombinant Human Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7), expressed in Escherichia coli (E. coli) and purified by standard chromatographic techniques. |
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Formulation Buffer |
20mM Tris, 150mM NaCl, pH8.0, containing 0.01% skl, 5%Trehalose. |
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Purity |
> 90% pure as determined by Silver stained SDS-PAGE analysis. Molecular Weight: ~54KDa |
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Storage |
Shipped at 2-8°C. Aliqote and Storet at-80C; Avoid repeated freeze/thaw cycles. |
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Background |
Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. |
