Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses
Function
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre- mRNA splicing. Cellular cofactor for lentiviral integration.
| Altername | DFS70; LEDGF; p52; p75; PAIP; Psip1; PSIP2 |
| Type | Rabbit Monoclonal Antibody |
| Storage/Stability | Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles. |
| Gene Name | PSIP1 |
| Protein Name | DFS70, LEDGF, PSIP2 |
| Human Gene Id | 11168 |
| Swiss-Prot No | O75475 |
| Recommended Dilutions | WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 |
| Molecular Weight | 60kDa |
| Isotype | Rabbit IgG |
| Cellular localization | Nucleus. Note=Remains chromatin-associated throughout the cell cycle |
Tissue Expression
Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions
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