| Immunogen |
Human recombinant protein fragment corresponding to amino acids 157-426 of human PLAT(NP_000921) produced in E.coli. |
| Target |
PLAT |
| Isotype |
IgG2b |
| Gene Name |
Homo sapiens plasminogen activator, tissue type (PLAT), transcript variant 1, mRNA. |
| Pathway |
Complement and coagulation cascades |
| Function |
Druggable Genome, Protease, Secreted Protein |
| Purification |
Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Form |
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Summary |
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| Tested Application |
WB 1:2000, IHC 1:150 |
| Storage Buffer |
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Storage |
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles. |
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