|
PERK Rabbit Monoclonal Antibody - Details |
|
Description |
Recombinant Rabbit Monoclonal Antibody |
|
Conjugation |
Unconjugated |
|
Modification |
Unmodified |
|
Isotype |
IgG, Kappa |
|
Clonality |
Monoclonal |
|
Form |
Liquid |
|
Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
|
Buffer |
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protective protein |
|
Purification |
Protein A |
|
Gene Name |
PERK |
|
Gene ID |
9451 |
|
SwissProt ID |
Q9NZJ5 |
|
Dilution Ratio |
WB 1:1000-1:5000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200 |
|
Molecular Weight |
Calculated MW:125kD;Observed MW:140kD |
|
Alternative Names |
EIF2AK3;PEK;PERK;Eukaryotic translation initiation factor 2-alpha kinase 3;PRKR-like endoplasmic reticulum kinase;Pancreatic eIF2-alpha kinase;HsPEK |
|
Background |
Cell localization:Endoplasmic reticulum membrane.The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. |
