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Oct-4 Rabbit Monoclonal Antibody - Details |
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Production Name |
Oct-4 Rabbit Monoclonal Antibody |
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Description |
Recombinant Rabbit Monoclonal Antibody |
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Conjugation |
Unconjugated |
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Modification |
Unmodified |
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Isotype |
IgG, Kappa |
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Clonality |
Monoclonal |
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Form |
Liquid |
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Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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Buffer |
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%protective protein |
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Purification |
Protein A |
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Gene Name |
POU5F1 |
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Gene ID |
5460 |
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SwissProt ID |
Q01860 |
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Dilution Ratio |
WB 1:2000-1:10000,IHC 1:1000-1:5000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200 |
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Molecular Weight |
Calculated MW:39kD;Observed MW:45kD |
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Alternative Names |
POU5F1;OCT3;OCT4;OTF3;POU domain; class 5, transcription factor 1;Octamer-binding protein 3;Oct-3;Octamer-binding protein 4;Oct-4;Octamer-binding transcription factor 3;OTF-3 |
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Research Area |
- |
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Background |
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Cell localization:Nucleus.This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation withThe Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One ofThe AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. |
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