Nrf2 Rabbit Polyclonal Antibody

Catalouge No BSAB-22P
Host Rabbit
Form Liquid
Reactivity Human, Mouse, Rat
Size 20μL | 50μL |100μL | 200μL
Price $ 100 | $ 125 | $ 230 | $ 390
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SKU: BSAB-22P Categories: ,

Background

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. domain: Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus., function: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. PTM: Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus. similarity: Belongs to the bZIP family. similarity: Belongs to the bZIP family. CNC subfamily. similarity: Contains 1 bZIP domain. subcellular location: Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents. subunit: Heterodimer. May bind DNA with an unknown protein. Interacts with KEAP1. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.,tissue specificity: Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.

Description Rabbit Polyclonal Antibody
Alternative Names NFE2L2; NRF2; Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor; erythroid derived 2, like 2
Gene Name NFE2L2
Isotype IgG
Application WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA
Clonality Polyclonal Antibody
Conjugation Unconjugated
Modification Unmodified
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Purification Affinity Purification
Gene ID 4780
SwissProt ID Q16236
Dilution Ratio WB 1:500-1:2000, IHC-P 1:100-1:300, IF-P/IF-F/ICC/IF 1:200-1:1000, ELISA 1:40000.
Molecular Weight 75-100kDa

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