| Product name: |
Nrf2 Rabbit pAb |
| Reactivity: |
Human,Mouse,Rat |
| Alternative Names: |
NFE2L2; NRF2; Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor; erythroid derived 2, like 2 |
| Source: |
Rabbit |
| Applications: |
WB, IHC, IF, ELISA |
| Recommended dilutions: |
Western Blot:1/500-1/2000 Immunohistochemistry:1/100-1/300 Immunofluorescence:1/200-1/1000 ELISA:1/40000 |
| Immunogen: |
Synthesized peptide derived from the C-terminal region of human Nrf2. at AA rangle； 530-610 |
| Storage: |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality: |
Polyclonal |
| Concentration: |
1mg/ml |
| Observed band: |
75-100kDa |
| GeneID（Human）: |
4780 |
| Background: |
NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up-regulation of genes in response to oxidative stress. It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes. The expression of NRF2 may be induced by oxidative stress |
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