| Description | Recombinant rabbit monoclonal antibody |
| Applications | WB |
| Form | Liquid |
| Conjugation | Unconjugated |
| Modification | Unmodified |
| Isotype | IgG |
| Buffer | Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% protective protein. Stable for 12 months from date of receipt. |
| Purification | Affinity purification |
| Alternative Names | EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4 |
| Gene Name | Nicotinic Acetylcholine Receptor alpha 4 |
| Gene ID | 1137 |
| SwissProt ID | P43681 |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Dilution Ratio | WB 1:2000-1:20000 |
| Molecular Weight | Calculated MW:70 kDa; Observed MW:70 kDa |
Background
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants.
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