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Neurofilament(NF-L) Mouse Monoclonal Antibody |
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Description |
Pathology Antibodies |
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Conjugation |
Unconjugated |
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Modification |
Unmodified |
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Isotype |
IgG1,Kappa |
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Clonality |
Monoclonal |
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Form |
Liquid |
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Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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Buffer |
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
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Purification |
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen. |
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Gene Name |
NEFL NF68 NFL |
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Gene ID |
Human:4747 |
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SwissProt ID |
Human:P07196 |
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Alternative Names |
Neurofilament light polypeptide;NF-L;68 kDa neurofilament protein;Neurofilament triplet L protein; |
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Dilution Ratio |
IHC 1:200-400;ELISA 1:500-5000 |
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Molecular Weight |
Calculated MW:68kDa,Observed MW:68kDa |
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Research Area |
Pathology |
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Background |
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. |
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Validated Image |
Human appendix tissue was stained with Anti-Neurofilament Antibody
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