| Product Info | |
| Description | Rabbit polyclonal antibody to MEF2C |
| Prediction | Pig(100%), Horse(100%), Sheep(100%), Dog(100%), Xenopus(100%) |
| Mol.Wt. | 51 kDa; 51kD(Calculated). |
| Uniprot | Q06413 |
| RRID | Rabbit IgG |
| Application | WB 1:500-1:2000, IHC 1:50-1:200, ChIP, IF/ICC 1:100-1:500 |
| Clonality | Polyclonal |
| Specificity | MEF2C Antibody detects endogenous levels of total MEF2C. |
| Conjugate | Unconjugated. |
| Purification | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific). |
| Storage | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt |
| Alias | C5DELq14.3; DEL5q14.3; MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C); MADS box transcription enhancer factor 2, polypeptide C; MEF2C; MEF2C_HUMAN; Myocyte enhancer factor 2C; Myocyte specific enhancer factor 2C; Myocyte-specific enhancer factor 2C; OTTHUMP00000222409; Similar to MADS box transcription enhancer factor 2 polypeptide C |
| Immunogens | |
| Immunogen | A synthesized peptide derived from human MEF2C, corresponding to a region within C-terminal amino acids. |
| Uniprot | Q06413(MEF2C_HUMAN) |
| Gene(ID) | MEF2C(4208) |
| Expression | Q06413 MEF2C_HUMAN:Expressed in brain and skeletal muscle. |
| Sequence | Q06413 MEF2C_HUMAN |
| Description | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. |
Research Backgrounds
Function: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform.
PTMs: Phosphorylation on Ser-59 enhances DNA binding activity (By similarity). Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity. Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation (By similarity). Sumoylated on Lys-391 with SUMO2 but not by SUMO1 represses transcriptional activity. Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.
Subcellular Location: Nucleus. Cytoplasm>Sarcoplasm.
Tissue Specificity: Expressed in brain and skeletal muscle.
Family & Domains: The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity. Belongs to the MEF2 family.
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