Background
Histone demethylase that demethylates ‘Lys-4’ of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed.
| Altername | AOF1; KDM1B; LSD2; Lysine-specific histone demethylase 1B; Lysine-specific histone demethylase 2 |
| Storage/Stability | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Swiss-Prot No | Q8NB78 |
| Recommended Dilutions | WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:60 FC 1:50 |
| Molecular Weight | 92kDa |
| Immunogen | A synthesized peptide derived from human LSD2 / AOF1 |
| Conjugate | Unconjugated |
| Modification | Unmodified |
| Purification | Affinity-chromatography |
| Specificity | LSD2 / AOF1 Antibody detects endogenous levels of total LSD2 / AOF1 |
| Formulation | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
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