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LEF1 Rabbit Monoclonal Antibody |
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Description |
Recombinant rabbit monoclonal antibody |
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Conjugation |
Unconjugated |
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Modification |
Unmodified |
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Isotype |
IgG |
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Clonality |
Monoclonal |
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Form |
Liquid |
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Buffer |
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein |
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Purification |
Affinity Purification |
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Gene Name |
LEF1 |
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Gene ID |
51176 |
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SwissProt ID |
Q9UJU2 |
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Dilution Ratio |
WB 1:500-1:1000,ICC/IF 1:50-1:200 |
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Molecular Weight |
Calculated MW: 44 kDa; Observed MW: 25-58 kDa |
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Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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Research Area |
Epigenetics and Nuclear Signaling |
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Background |
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). |
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Validated Image |
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