Summary
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.
| Altername | ADCADN; AIM; CXXC9; DNMT; HSN1E; MCMT; m.HsaI; DNMT1 |
| Type | Monoclonal Antibodies |
| Purification | Affinity purification |
| Immunogen | A synthesized peptide derived from human DNMT1. |
| Positive control | Jurkat, HeLa, 293T |
| Isotype | IgG |
| Gene ID | 1786 |
| Swiss-Prot No | P26358 |
| Storage/Stability | Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles. |
| Storage Buffer | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Dilution | WB 1:500 - 1:2000 | IHC 1:50 - 1:200 | IF 1:50 - 1:200 | IP 1:50 - 1:200 | ChIP 1:50 - 1:200 |
| Applications | IF (Mus musculus) |
Reviews
There are no reviews yet.