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Keap1 Rabbit Monoclonal Antibody - Details |
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Production Name |
Keap1 Rabbit Monoclonal Antibody |
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Description |
Recombinant Rabbit Monoclonal Antibody |
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Conjugation |
Unconjugated |
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Modification |
Unmodified |
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Isotype |
IgG, Kappa |
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Clonality |
Monoclonal |
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Form |
Liquid |
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Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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Buffer |
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%protective protein |
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Purification |
Protein A |
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Gene Name |
KEAP1 |
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Gene ID |
9817 |
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SwissProt ID |
Q14145 |
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Dilution Ratio |
WB 1:2000-1:10000,IHC 1:200-1:1000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200 |
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Molecular Weight |
Calculated MW:70kD;Observed MW:60-70kD |
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Alternative Names |
Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19) |
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Research Area |
- |
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Background |
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Cell localization:Cytoplasm, Nucleus.kelch like ECH associated protein 1(KEAP1) Homo sapiens This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. |
