|
Integrin alpha 6 (19T9) Rabbit Monoclonal Antibody - Details |
|
Description |
Recombinant rabbit monoclonal antibody |
|
Conjugation |
Unconjugated |
|
Modification |
Unmodified |
|
Isotype |
IgG |
|
Clonality |
Monoclonal |
|
Form |
Liquid |
|
Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
|
Buffer |
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
|
Purification |
Affinity purification |
|
Gene Name |
ITGA6 |
|
Alternative Names |
ITGA6; CD49 antigen-like family member F; VLA-6; CD49f; |
|
Gene ID |
3655 |
|
SwissProt ID |
P23229 |
|
Molecular Weight |
127kDa |
|
Dilution Ratio |
WB 1:500-1:2000,IHC 1:200-1:500,IF-P 1:200-1:500 |
|
Background |
|
Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling |
Reviews
There are no reviews yet.