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Hemoglobin Subunit Beta Antibody |
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Description |
Rabbit Polyclonal Antibody To Hemoglobin Subunit Beta |
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Mol.Wt |
15kDa(Observed); 16kD(Calculated). |
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Uniprot |
P68871 |
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Application |
WB 1:500-1:2000, IHC 1:50-1:200 |
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Prediction |
Pig(100%), Bovine(%), Horse(%), Rabbit(%), Chicken(%) |
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Clonality |
Polyclonal |
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Specificity |
Hemoglobin subunit beta Antibody detects endogenous levels of total Hemoglobin subunit beta. |
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Conjugate |
Unconjugated |
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Purification |
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin. |
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Storage |
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt |
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Alternative Name |
ba1; Beta 1 globin; beta globin; beta globin chain; BETA GLOBIN TYPE; BETA THALASSEMIAS; Beta-A1-globin; CD113t C; CD113t-C; ERYTHREMIA; HBB; Hemoglobin beta 1 chain; hemoglobin beta chain; hemoglobin beta chain complex; Hemoglobin beta chain, major form; HEMOGLOBIN BETA LOCUS; Hemoglobin beta-1 chain; Hemoglobin subunit beta-1; METHEMOGLOBINEMIA |
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Immunogen |
A synthesized peptide derived from human Hemoglobin subunit beta, corresponding to a region within N-terminal amino acids. |
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Gene(ID) |
HBB(3043) |
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Uniprot |
P68871(HBB_HUMAN) |
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Expression |
P68871 HBB_HUMAN: Red blood cells |
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PTMs |
Glucose reacts non-enzymatically with the N-terminus of the beta chain to form a stable ketoamine linkage. This takes place slowly and continuously throughout the 120-day life span of the red blood cell. The rate of glycation is increased in patients with diabetes mellitus. |
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Tissue Specificity |
Red blood cells. |
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Family & Domains |
Red blood cells. |
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Function |
Involved in oxygen transport from the lung to the various peripheral tissues. LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure. functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation. |
