| Alternative Names | HDAC3; Histone deacetylase 3; HD3; RPD3-2; SMAP45 |
| Description | Recombinant Rabbit Monoclonal Antibody |
| Clonality | Monoclonal |
| Form | Liquid |
| Conjugation | Unconjugated |
| Modification | Unmodified |
| Isotype | IgG |
| Buffer | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein |
| Purification | Affinity Purification |
| Gene Name | HDAC3 |
| Gene ID | 8841 |
| SwissProt ID | O15379 |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Dilution Ratio | WB 1:500-1:1000,IHC 1:50-1:100,ICC/IF 1:50-1:200,IP 1:20-1:50 |
| Molecular Weight | Calculated MW: 49 kDa; Observed MW: 49 kDa |
Background
HDAC3 is a nuclear and cytoplasmic protein that deacetylates both histone (H2A, H3, H4) and non-histone substrates (RelA, SRY, p53, MEF2, PCAF and p300/CBP). HDAC3 deacetylase activity is stimulated by interactions with the N-CoR and SMRT co-repressor proteins. Together, these three proteins form a functional complex that represses transcription associated with nuclear hormone receptors and other transcription factors, including Rev-Erb, COUP-TF, DAX1, MAD and Pit-1.
Research Area
Epigenetics and Nuclear Signaling