|
GFRα-1 Rabbit Polyclonal Antibody - Details |
|
Description |
Rabbit polyclonal Antibody |
|
Conjugation |
Unconjugated |
|
Modification |
Unmodified |
|
Isotype |
IgG |
|
Clonality |
Polyclonal |
|
Form |
Liquid |
|
Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
|
Buffer |
Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N. |
|
Purification |
Affinity purification |
|
Gene Name |
GFRA1 |
|
Alternative Names |
GFRA1; GDNFRA; RETL1; TRNR1; GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1 |
|
Gene ID |
2674 |
|
SwissProt ID |
P56159 |
|
Dilution Ratio |
WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:5000-1:20000 |
|
Background |
|
This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016],function: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. similarity: Belongs to the GDNFR family.,subunit:2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET. |
Reviews
There are no reviews yet.