|
Fos B Polyclonal Antibody - Details |
|
Molecular Weight |
35928Da |
|
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
|
Immunogen |
The antiserum was produced against synthesized peptide derived from human FosB. AA range:12-61 |
|
Gene Name |
FOSB |
|
Dilution |
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
|
Protein Name |
Protein fosB |
|
Human Gene Id |
2354 |
|
Human Swiss Prot No |
P53539 |
|
Mouse Gene Id |
14282 |
|
Mouse Swiss Prot No |
P13346 |
|
Specificity |
Fos B Polyclonal Antibody detects endogenous levels of Fos B protein. |
|
Formulation |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
|
Concentration |
1 mg/ml |
|
Storage Stability |
-20°C/1 year |
|
Other Name |
FOSB; G0S3; Protein fosB; G0/G1 switch regulatory protein 3 |
|
Observed Band(KD) |
35 |
|
Function |
function:FosB interacts with Jun proteins enhancing their DNA binding activity.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Fos subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer. |
|
Subcellular Location |
Nucleus |
|
Background |
|
FosB proto-oncogene, AP-1 transcription factor subunit(FOSB) Homo sapiens The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Reviews
There are no reviews yet.