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Fos B Polyclonal Antibody - Details |
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Molecular Weight |
35928Da |
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Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
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Immunogen |
The antiserum was produced against synthesized peptide derived from human FosB. AA range:12-61 |
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Gene Name |
FOSB |
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Dilution |
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
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Protein Name |
Protein fosB |
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Human Gene Id |
2354 |
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Human Swiss Prot No |
P53539 |
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Mouse Gene Id |
14282 |
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Mouse Swiss Prot No |
P13346 |
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Specificity |
Fos B Polyclonal Antibody detects endogenous levels of Fos B protein. |
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Formulation |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
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Concentration |
1 mg/ml |
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Storage Stability |
-20°C/1 year |
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Other Name |
FOSB; G0S3; Protein fosB; G0/G1 switch regulatory protein 3 |
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Observed Band(KD) |
35 |
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Function |
function:FosB interacts with Jun proteins enhancing their DNA binding activity.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Fos subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer. |
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Subcellular Location |
Nucleus |
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Background |
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FosB proto-oncogene, AP-1 transcription factor subunit(FOSB) Homo sapiens The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
