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EPO Antibody |
|
Description |
Rabbit Polyclonal Antibody To EPO |
|
Mol.Wt |
21 kDa(Observed); 21kD(Calculated). |
|
Uniprot |
P01588 |
|
Application |
WB 1:500-1:2000, IHC 1:50-1:200 |
|
Prediction |
Pig(80%), Bovine(%), Horse(%), Sheep(%), Rabbit(%), Dog(%) |
|
Clonality |
Polyclonal |
|
Specificity |
EPO Antibody detects endogenous levels of total EPO. |
|
Conjugate |
Unconjugated |
|
Purification |
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin. |
|
Storage |
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt. |
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Alternative Name |
EP; EPO alpha; EPO; Epoetin; Erythropoetin; Erythropoietin precursor; MVCD2; |
|
Immunogen |
A synthesized peptide derived from human EPO, corresponding to a region within the internal amino acids. |
|
Gene(ID) |
EPO(2056) |
|
Uniprot |
P01588(EPO_HUMAN) |
|
Expression |
P01588 EPO_HUMAN: Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals. |
|
Description |
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. |
|
Subcellular Location |
Secreted |
|
Tissue Specificity |
Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals. |
|
Family & Domains |
Belongs to the EPO/TPO family. |
|
Function |
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. |
