Background
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
| Altername | TBRS; DNMT3A2; M.HsaIIIA |
| Storage/Stability | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Swiss-Prot No | Q9Y6K1 |
| Recommended Dilutions | WB: 1:1000, ICC/IF: 1:200, FC: 1:20-1:100 |
| Molecular Weight | 130 kDa |
| Immunogen | A synthetic peptide of human Dnmt3a |
| Conjugate | Unconjugated |
| Modification | Unmodified |
| Purification | Affinity Purification |
| Specificity | IgG |
| Formulation | Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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