| Altername | AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI |
| Recommended Dilutions | WB: 1:1000 IHC: 1:100 ICC/IF: 1:200-1:1000 FC: 1:100 |
| Formulation | Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| Purification | Affinity Purification |
| Storage/Stability | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Specificity | IgG |
| Molecular Weight | 183 kDa |
| Immunogen | A synthetic peptide of human Dnmt1 |
| Conjugate | Unconjugated |
| Modification | Unmodification |
| Swiss-Prot No | P26358 |
Background
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.
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