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Dithiothreitol

CAS No: 3483-12-3

Catalouge No BSCHM-005D
Mol. Formula C4H10O2S2
Mol. Weight 371.39
HSN Code 29309099
CAS 3483-12-3
Pack Size 1 GM | 5 GM | 25 GM | 100 GM
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SKU: BSCHM-005D Categories: ,

Dithiothreitol (DTT) is the common name for a small-molecule redox reagent also known as Cleland’s reagent.

Dithiothreitol, Molecular Biology - Specification
Synonyms Cleland’s reagent, DTT
Categories Biochemicals & Reagents, Carbohydrates
Assay 99%+
Appearance (Form) Powder
Appearance (Colour) White
Melting Point 41 °C ± 3°
Solubility H2O: soluble 0.1 M at 20 °C, clear, colorless
pH 4.0-6.5 (25 °C, 0.1 M in H2O)
Storage temp 2-8 °C
Dithiothreitol, Etra Pure (98%+) - Specification
Synonyms (2S,3S)-1,4-dimercaptobutane-2,3-diol, D-threo-1,4-dimercaptobutane-2,3-diol, D-threo-1,4-dimercapto-2,3-butanediol, 1,4-dithio-D-threitol, Cleland's reagent, Reductacryl
Categories Biochemicals & reagents, Carbohydrates A to Z
Grade Extra Pure
Assay (Min) 98%+
Appearance (Form) Crystals or lumps or powder
Appearance (Colour) White
Melting point 41-44 °C(lit.)
Solubility H2O: soluble50 mg/mL, clear, colorless to faint yellow or tan
Storage temp. 2-8 °C

Safety Information

  • Hazard Codes Xn
  • Risk Statements 22-36/37/38
  • Safety Statements 26-36
  • WGK Germany 3

Dithiothreitol - for molecular biology, 99%  used as an oxidizing agent. Its principal advantage is that effectively no mixed-disulfide species are populated, in contrast to other agents such as glutathione.

Dithiothreitol, extra pure - 98%+ Cas 3483-12-3 - used as a reducing or "deprotecting" agent for thiolated DNA. The terminal sulfur atoms of thiolate DNA have a tendency to form dimers in solution, especially in the presence of oxygen.