Background
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.
| Description | Rabbit Monoclonal Antibody |
| Alternative Names | H3K4me; H3 histone; HIST1H3A; Histone cluster 1; H3a |
| Gene Name | DiMethyl-Histone H3 (Lys4) Rabbit Monoclonal Antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC/IF |
| Clonality | Monoclonal Antibody |
| Conjugation | Unconjugated |
| Modification | Unmodified |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Purification | Affinity Purification |
| Gene ID | 8356 |
| SwissProt ID | P68431 |
| Dilution Ratio | WB: 1:1000 IHC-P: 1:200-1:2000 ICC/IF: 1:200-1:500 |
| Molecular Weight | Calculated MW:15 kDa; Observed MW:17 kDa |
| Research Area | Epigenetics and Nuclear Signaling |
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