|
COX-2 Mouse Monoclonal Antibody |
|
Description |
Pathology Antibodies |
|
Conjugation |
Unconjugated |
|
Modification |
Unmodified |
|
Isotype |
IgG2b,Kappa |
|
Clonality |
Monoclonal |
|
Form |
Liquid |
|
Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
|
Buffer |
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
|
Purification |
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen. |
|
Gene Name |
PTGS2 COX2 |
|
Gene ID |
Human:5743 |
|
SwissProt ID |
Human:P35354 |
|
Dilution Ratio |
IHC 1:200-400;ELISA 1:500-5000 |
|
Molecular Weight |
Calculated MW:69kDa,Observed MW:70kDa |
|
Background |
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. |
|
Validated Image |
Human Colon carcinoma tissue was stained with Anti-COX-2 Antibody
|
