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CD44 (19J7) Rabbit Monoclonal Antibody - Details |
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Production Name |
CD44 (19J7) Rabbit Monoclonal Antibody |
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Description |
Recombinant rabbit monoclonal antibody |
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Conjugation |
Unconjugated |
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Modification |
Unmodified |
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Isotype |
IgG |
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Clonality |
Monoclonal |
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Form |
Liquid |
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Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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Buffer |
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
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Purification |
Affinity purification |
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Gene Name |
CD44 |
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Gene ID |
960 |
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SwissProt ID |
P16070 |
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Dilution Ratio |
WB 1:500-1:2000,IHC 1:500-1:2000,IP 1:20-1:50,IF-P 1:500-1:2000 |
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Molecular Weight |
82kDa |
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Alternative Names |
LHR; CD44; CD44 antigen; CDw44; chondroitin sulfate proteoglycan 8; CSPG8; Epican; HCELL; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; HSA; HUTCH1; HUTCHI; Hyaluronate receptor; MDU2; MDU3; MIC4; MUTCH1; PGP1; Phagocytic glycoprotein 1; Soluble CD44 |
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Research Area |
Immunology |
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Background |
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Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. |
