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Caspase 2 Antibody |
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Description |
Rabbit Polyclonal Antibody To Caspase 2 |
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Mol.Wt |
48,30,12kDa(Observed); 51kD(Calculated). |
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Uniprot |
P42575 |
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Application |
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC |
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Clonality |
Polyclonal |
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Specificity |
Caspase 2 Antibody detects endogenous levels of total Caspase 2. |
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Conjugate |
Unconjugated. |
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Purification |
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin. |
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Storage |
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt |
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Alternative Name |
CASP 2; CASP-2; Casp2; CASP2_HUMAN; Caspase 2; Caspase 2 apoptosis related cysteine peptidase; Caspase-2 subunit p12; Caspase2; ICH 1; ICH 1 protease; ICH 1L; ICH1; ICH1 protease; ICH1L; NEDD-2; NEDD2; Neural precursor cell expressed developmentally down-regulated protein 2; PPP1R57; Protease ICH-1; Protein phosphatase 1 regulatory subunit 57 |
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Immunogen |
A synthesized peptide derived from human Caspase 2, corresponding to a region within the internal amino acids. |
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Gene(ID) |
CASP2(835) |
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Uniprot |
P42575(CASP2_HUMAN) |
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Expression |
P42575 CASP2_HUMAN: Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle. |
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Tissue Specificity |
Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle. |
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Family & Domains |
The CARD domain mediates a direct interaction with CRADD. Belongs to the peptidase C14A family. |
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Function |
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress. |
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PTMs |
The mature protease can process its own propeptide, but not that of other caspases. |
