This plate format is designed for laboratories processing multiple samples simultaneously. It extends the spin column principle into a high-throughput configuration while maintaining comparable nucleic acid binding behavior.

It is typically used in workflows where throughput and consistency across samples are prioritized over maximizing individual sample yield.

Based on the negatively charged DNA skeleton, it has a high affinity for positively charged glass fibers. In high salt and ethanol solutions, DNA/RNA binds to glass fiber and interacts with hydrophilic matrix on silica through hydrogen bond. DNA/RNA is tightly bound. All pollutants can be removed by washing solution. At high salt concentration, nucleic acids selectively bind to silica gel membrane, while other pollutants, mainly proteins, are removed by membrane washing.