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Bax Rabbit Monoclonal Antibody |
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Description |
Recombinant Rabbit Monoclonal Antibody |
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Conjugation |
Unconjugated |
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Modification |
Unmodified |
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Isotype |
IgG |
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Clonality |
Monoclonal |
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Form |
Liquid |
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Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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Buffer |
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein |
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Purification |
Affinity Purification |
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Gene Name |
BAX |
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Gene ID |
581 |
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SwissProt ID |
Q07812 |
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Alternative Names |
Apoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4 |
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Buffer |
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein |
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Molecular Weight |
Calculated MW: 21 kDa; Observed MW: 21 kDa |
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Dilution Ratio |
WB 1:500-1:1000,IP 1:20-1:50 |
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Research Area |
Cell Biology |
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Background |
Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis. |
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Validated Image |
Western blot analysis of Bax in C6, 3T3, Hela lysates using Bax antibody.
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