| AR-β2 Rabbit Polyclonal Antibody - Details | |
| Description | Rabbit Polyclonal Antibody |
| Conjugation | Unconjugated |
| Modification | Unmodified |
| Isotype | IgG |
| Clonality | Polyclonal |
| Form | Liquid |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Buffer | Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N. |
| Purification | Affinity Purification |
| Gene Name | ADRB2 |
| Gene ID | 154 |
| SwissProt ID | P07550 |
| Dilution Ratio | WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:200-1:1000,ELISA 1:5000-1:10000,FC 1:200-1:400 |
| Molecular Weight | 47kDa |
| Alternative Names | ADRB2; ADRB2R; B2AR; Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor |
| Background | This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by Ref Seq, Jul 2008],disease: Polymorphic forms of ADRB2 could impart some form of nocturnal asthma., function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.,PTM: Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes DE palmitoylation and further allows Ser-345 and Ser-346 phosphorylation., PTM: Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM: Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Binds SLC9A3R1 and GPRASP1 |
AR-β2 Rabbit Polyclonal Antibody
| Catalouge No | BSAB-235P |
| Host | Rabbit |
| Reactivity | Human, Rat, Mouse |
| Applications | WB,IHC,ICC/IF,ELISA,FC |
| Size | 20μL | 50μL | 100μL | 200μL |
| Price | POR |
Immunofluorescence analysis of HeLa cells, using Adrenergic Receptor beta2 Antibody. The picture on the right is blocked with the synthesized peptide.
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Adrenergic Receptor beta2 Antibody. The picture on the right is blocked with the synthesized peptide.