| Size | 100µg |
| Form | Liquid |
| Purification | Protein G Purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| IMMUNOGEN INFORMATION | |
| Immunogen | interleukin 1, beta |
| Observed MW | 35kDa |
| APPLICATION | |
| Tested Application | ELISA, IHC, WB |
| Recommended Dilution | WB: 1:1000-1:4000; IHC: 1:50-1:500 |
Background
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
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