| Synonyms | Apoptotic cysteine protease, Apoptotic protease Mch 5, Casp 8, CASP8, Caspase 8, Caspase 8/p18, Caspase8, FADD like ICE, FLICE, ICE like apoptotic protease 5, MACH, MCH5 |
| Form | Liquid |
| Purification | Immunogen Affinity Purified |
| Clonality | Polyclonal |
| Purity | ≥95% as determined by SDS-PAGE |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| IMMUNOGEN INFORMATION | |
| Immunogen | Caspase 8, Apoptosis-related Cysteine Peptidase |
| Observed MW | 50-55 kDa, 25-32 kDa |
| APPLICATION | |
| Tested Application | ELISA, WB, IHC, IP, IF |
| Recommended Dilution | WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:50-1:100; IF: 1:10-1:100 |
Background
Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816). It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. This antibodycan recognize pro-and cleaved-caspase 8.
Reviews
There are no reviews yet.