| APPLICATION | |
| Tested Application | ELISA, WB, IHC |
| Recommended Dilution | WB: 1:500-1:2000, IHC: 1:20-1:200 |
| IMMUNOGEN INFORMATION | Immunogen: caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) |
| Observed MW:45-47 kDa, 30 kDa, 35 kDa | |
| Size | 100µg |
| Form | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
BACKGROUND
CASP1 (caspase-1) is also named IL1BC or IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B) , IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products (PMID:21804020) . It has 5 isoforms produced by alternative splicing.
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