Anti- Angiotensinogen Antibody

Product Name Anti- Angiotensinogen Antibody
Catalogue No BS-49300BANF
Source Rabbit
Size 100µg / liquid Form
Reactivity Human
Isotype IGG
Tested Application ELISA, WB, IHC, IF
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Synonyms AGT, Ang I Angiotensin 2, Ang II Angiotensin 3, Ang III, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensinogen, ANHU, Des Asp[1] angiotensin II, FLJ92595, FLJ97926, Serpin A8, SERPINA8
Form Liquid
Purification Immunogen Affinity Purified
Clonality Polyclonal
Purity ≥95% as determined by SDS-PAGE
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
IMMUNOGEN INFORMATION
Immunogen angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Observed MW 53 kDa
APPLICATION
Tested Application ELISA, WB, IF, IHC
Recommended Dilution WB :1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100

Background

Angiotensinogen is a precursor of angiotensin II (Ang II) , is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.


Immunohistochemistry of paraffin-embedded human hepatocirrhosis tissue slide using BS-49300BANF (AGT Antibody) at dilution of 1:50
 


human plasma tissue were subjected to SDS PAGE followed by western blot with BS-49300BANF (AGT antibody) at dilution of 1:1000

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