Synonyms | AGT, Ang I Angiotensin 2, Ang II Angiotensin 3, Ang III, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensinogen, ANHU, Des Asp[1] angiotensin II, FLJ92595, FLJ97926, Serpin A8, SERPINA8 |
Form | Liquid |
Purification | Immunogen Affinity Purified |
Clonality | Polyclonal |
Purity | ≥95% as determined by SDS-PAGE |
Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
IMMUNOGEN INFORMATION | |
Immunogen | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
Observed MW | 53 kDa |
APPLICATION | |
Tested Application | ELISA, WB, IF, IHC |
Recommended Dilution | WB :1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100 |
Background
Angiotensinogen is a precursor of angiotensin II (Ang II) , is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
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