| Size | 100µg / liquid Form |
| Form | Liquid |
| Purification | Immunogen Affinity Purified |
| Specificity | 15 Lipoxygenase 1 Antibody detects endogenous levels of total 15 Lipoxygenase 1 |
| Purity | ≥95% as determined by SDS-PAGE |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| IMMUNOGEN INFORMATION | |
| Immunogen | arachidonate 15-lipoxygenase, type B |
| Observed MW | 76 kDa |
| APPLICATION | |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:20-1:200 |
Background
In humans, there are 6 functional lipoxygenases genes. Two of them encode for arachidonic acid 12-lipoxygenating (ALOX12, ALOX12B) and two for 15-lipoxygenating enzymes (ALOX15, ALOX15B) . ALOX15B has been described as the most abundant 15-lipoxygenating enzyme species in human carotid atherosclerotic lesions and to be associated with cerebrovascular symptoms. (PMID:24373925) . ALOX15B has 4 isoforms produced by alternative splicing with the MW of 76, 67, 69 and 73 kDa.
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