| Alternative Names | Long-chain-fatty-acid--CoA ligase 4;Long-chain acyl-CoA synthetase 4;LACS 4 |
| Description | Rabbit Polyclonal Antibody |
| Clonality | Monoclonal |
| Form | Liquid |
| Conjugation | Unconjugated |
| Modification | Unmodified |
| Isotype | IgG |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinitychromatography using epitope-specific immunogen. |
| Gene Name | ACSL4 ACS4 FACL4 LACS4 |
| Gene ID | Human:2182,Mouse:50790,Rat:50790 |
| SwissProt ID | Human:O60488,Mouse:Q9QUJ7,Rat:O35547.Synthesized peptide derived from human |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles |
| Dilution Ratio | WB 1:500-2000 |
| Molecular Weight | Observed MW:75kDa |
Background
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants.
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