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53BP1 Rabbit Monoclonal Antibody - Summary |
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Description |
Rabbit Monoclonal Antibody |
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Alternative Names |
TP53; p202; 53BP1; TDRD30; p53BP1 |
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Gene Name |
53BP1 |
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Isotype |
IgG |
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Form |
Liquid |
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Clonality |
Monoclonal Antibody |
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Conjugation |
Unconjugated |
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Modification |
Unmodified |
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Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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Purification |
Affinity Purification |
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Gene ID |
7158 |
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SwissProt ID |
Q12888 |
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Dilution Ratio |
WB: 1:1000 IHC: 1:100-1:200 ICC/IF: 1:100-1:200 FC: 1:20 |
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Molecular Weight |
Calculated MW:214 kDa; Observed MW:450 kDa |
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Background |
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This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms |
