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Recombinant-Human PDGF-BB |
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Description |
Recombinant protein expressed in Escherichia coli (E. coli) and purified by standard chromatographic techniques and supplied as Freeze-dried powder. The protein contains a N-terminal His Tags. |
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Formulation Buffer |
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300; Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL |
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Purity |
> 90% pure as determined by SDS-PAGE analysis. Molecular Weight: ~21 KDa |
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Storage |
Shipped at 2-8°C. Aliqote and Storet at-80C; Avoid repeated freeze/thaw cycles. |
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Background |
The Platelet-Derived Growth Factor (PDGF) family consists of proteins derived from four genes (PDGF-A, -B, -C and -D) that form four disulfide-linked homodimers (PDGF-AA, -BB, -CC, -DD) and one heterodimer (PDGF-AB). These proteins and the related VEGF family proteins share the conserved PDGF/VEGF homology domain characterized by a pattern of highly conserved cysteine residues, which form the cysteine knot motif. PDGF-B is synthesized as a pre-pro-protein, which has a signal peptide, a mature region, an N- terminal pro-peptide, and a C-terminal extension. |
