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Recombinant Human Hypoxia Inducible Factor 1 Alpha (HIF1a) |
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Description |
Recombinant Human Hypoxia Inducible Factor 1 Alpha (HIF1a),expressed in Escherichia coli (E. coli) and purified by standard chromatographic techniques. |
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Formulation Buffer |
20mM Tris, 150mM NaCl, pH8.0, containing 0.01% skl, 5%Trehalose. |
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Purity |
> 95% pure as determined by Silver stained SDS-PAGE analysis. Molecular Weight: ~40KDa |
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Storage |
Shipped at 2-8°C. Aliqote and Storet at-80C; Avoid repeated freeze/thaw cycles. |
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Background |
Hypoxia Inducible Factor 1 Alpha (HIF1a) is a basic helix-loop-helix PAS domain containing protein, and is considered as the master transcriptional regulator of cellular and developmental response to hypoxia. The dysregulation and overexpression of HIF1A by either hypoxia or genetic alternations have been heavily implicated in cancer biology, as well as a number of other pathophysiologies, specifically in areas of vascularization and angiogenesis, energy metabolism, cell survival, and tumor invasion |
