Mini Portable Grinder achieves crushing and grinding effects through the inertia of grinding balls/beads, which drive them to impact the sample material on the curved inner surface at high energy. The motion of the adapter can be superimposed with the movement of the internal beads to thoroughly mix the sample. The product is suitable for multi-scenario, diversified sample pretreatment (grinding) applications, including human tissues (hair, skin, liver, etc.), animal tissues, plant tissues (roots, stems, leaves, fruits, etc.), and environmental samples (soil, etc.).