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SIAH1 Rabbit Polyclonal Antibody - Details |
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Description |
Rabbit Polyclonal Antibody |
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Conjugation |
Unconjugated |
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Modification |
Unmodified |
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Isotype |
IgG |
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Clonality |
Polyclonal |
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Form |
Liquid |
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Storage |
Aliquot and store at -20°C (valid for 12 months). Avoid freeze/thaw cycles. |
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Buffer |
PBS containing 50% glycerol, 0.5% Protective protein and 0.02% sodium azide. |
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Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
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Gene Name |
SIAH1 |
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Gene ID |
Human:6477,Rat:140941 |
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SwissProt ID |
Human:Q8IUQ4,Rat:Q920M9 |
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Dilution Ratio |
WB 1:500-2000 |
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Molecular Weight |
Calculated MW:31kDa |
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Alternative Names |
HUMSIAH |
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Immunogen |
Synthesized peptide derived from human SIAH1 AA range: 157-207 |
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Concentration |
1 mg/ml.The concentration of this product may be batch-dependent |
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Background |
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson & aposs disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. |
