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c-Myc Rabbit Polyclonal Antibody - Details |
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Description |
Rabbit Polyclonal Antibody |
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Conjugation |
Unconjugated |
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Modification |
Unmodified |
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Isotype |
IgG |
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Clonality |
Polyclonal |
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Form |
Liquid |
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Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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Buffer |
Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% New type preservative N. |
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Purification |
Affinity purification |
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Gene Name |
MYC |
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Gene ID |
4609 |
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SwissProt ID |
P01106 |
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Dilution Ratio |
WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:200-1:1000,ELISA 1:20000-1:40000 |
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Molecular Weight |
50,(also ~60kDa in some samples) |
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Alternative Names |
MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64 |
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Research Area |
Stem cell pathway; Cell_Cycle_G1S;Cell_Cycle_G2M_DNA; WNT;WNT-T CELL;β-Catenin; ErbB/HER; MAPK_ERK_Growth;MAPK_G_Protein; PI3K/Akt; Protein_Acetylation |
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Background |
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. disease: A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.,disease:Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. function: Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. online information encrypts: Phosphorylated by PRKDC. similarity: Contains 1 basic helix-loop-helix (bHLH) domain. subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. |
