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NBN Mouse Monoclonal Antibody - Details |
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Description |
Mouse monoclonal Antibody |
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Conjugation |
Unconjugated |
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Modification |
Unmodified |
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Isotype |
Mouse IgG2a |
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Clonality |
Monoclonal |
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Form |
Liquid |
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Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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Buffer |
Purified antibody in PBS with 0.05% sodium azide. |
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Purification |
Affinity Purification |
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Gene Name |
NBN |
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Alternative Names |
ATV; NBS; P95; NBS1; AT-V1; AT-V2 |
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Gene ID |
4683 |
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SwissProt ID |
O60934 |
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Dilution Ratio |
WB 1:500-1:2000,IHC 1:200-1:1000,ICC 1:200-1:1000,ELISA 1:5000-1:20000,FC 1:200-1:400 |
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Molecular Weight |
85kDa |
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Research Area |
- |
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Background |
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation |
